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Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5OH3PO4H2O and a molecular weight of 523.32. The structural formula is:CT, NJ, ME, NHAccording to The American Psychiatric Association, 5% of children in the US have ADHD. However, studies have shown that 11% of children aged between 4 and 17 years had ADHD in 2011. The prevalence of ADHD is increasing, from 7.8% in 2003 to 11% in 2011. ADHD is more common in boys compared to girls (13.2% and 5.6% respectively).COMBIGAN (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, sterile, is a relatively selective alpha-2 adrenergic receptor agonist with a non-selective beta-adrenergic receptor inhibitor (ical intraocular pressure lowering agent).

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