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Methotrexate The best choice of allergy medication is one which relieves symptoms without interfering with everyday tasks. Many allergy sufferers are finding that the newer, non-sedating antihistamines meet both these important parameters. It's also important to find an allergy medication that can safely be used for the long term, since for many, allergies last an entire season – if not the entire year. And finally, allergy medications should minimally react with other medications.

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