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buy tadalafil 4.6 Fertility, pregnancy and lactationStudies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). Sildenafil is approximately 4,000-fold more selective for PDE5 compared to PDE3. PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision [see Clinical Pharmacology (12.2)].Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

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If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking. real cialis online This drug has lesser affinity for isoenzyme PDE6, an enzyme found in the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels.Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water.

1996 republican presidential candidate Bob Dole, 74, praised the erection inducer on "Larry King Live." A participant in Viagra's clinical trials, the former Senate Majority Leader pronounced it a "great" and "effective" drug. When pressed by reporters for her appraisal, Elizabeth Dole tittered in approval: "Let me just say - he was in the protocol, and it is a great drug." (It's safe to assume the American public could have lived without that image.)